Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.

ABSTRACT: A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.

SUBMITTER: Sanchez-Murcia PA 

PROVIDER: S-EPMC7236230 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature