Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
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ABSTRACT:
SUBMITTER: Sanchez-Murcia PA
PROVIDER: S-EPMC7236230 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
Sánchez-Murcia Pedro A PA de Castro Sonia S García-Aparicio Carlos C Jiménez M Angeles MA Corona Angela A Tramontano Enzo E Sluis-Cremer Nicolas N Menéndez-Arias Luis L Velázquez Sonsoles S Gago Federico F Camarasa María-José MJ
ACS medicinal chemistry letters 20200124 5
A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors. ...[more]
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