Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study.

ABSTRACT: BACKGROUND:Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diagnosis PA is associated with less fatigue in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term fatigue in CRC survivors. METHODS:This study used a German population-based cohort of 1781 individuals, diagnosed with CRC in 2003-2014, and alive at five-year follow-up (5YFU). Physical activity was assessed at diagnosis and at 5YFU. Fatigue was assessed by the Fatigue Assessment Questionnaire and the EORTC Quality of Life Questionnaire-Core 30 fatigue subscale at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and fatigue at 5YFU. RESULTS:No evidence was found that pre-diagnosis PA was associated with less fatigue in long-term CRC survivors. Pre-diagnosis work-related PA and vigorous PA were even associated with higher levels of physical (Beta (ß)?=?2.52, 95% confidence interval (CI)?=?1.14-3.90; ß?=?2.03, CI?=?0.65-3.41), cognitive (ß?=?0.17, CI?=?0.05-0.28; ß?=?0.13, CI?=?0.01-0.25), and affective fatigue (ß?=?0.26, CI?=?0.07-0.46; ß?=?0.21, CI?=?0.02-0.40). In cross-sectional analyses, post-diagnosis PA was strongly associated with lower fatigue on all scales. CONCLUSIONS:In this study, pre-diagnosis PA does not appear to be associated with less fatigue among long-term CRC survivors. Our results support the importance of ongoing PA in long-term CRC survivors. Our findings might be used as a basis for further research on specific PA interventions to improve the long-term outcome of CRC survivors.

SUBMITTER: Eyl RE 

PROVIDER: S-EPMC7236466 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature