Ontology highlight
ABSTRACT:
SUBMITTER: Craig E
PROVIDER: S-EPMC7236580 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Craig Emma E Dillingham Christopher M CM Milczarek Michal M MM Phillips Heather M HM Davies Moira M Perry James C JC Vann Seralynne D SD
Wellcome open research 20200515
<b>Background:</b> Neuronal plasticity is thought to underlie learning and memory formation. The density of dendritic spines in the CA1 region of the hippocampus has been repeatedly linked to mnemonic processes. Both the number and spatial location of the spines, in terms of proximity to nearest neighbour, have been implicated in memory formation. To examine how spatial training impacts synaptic structure in the hippocampus, Lister-Hooded rats were trained on a hippocampal-dependent spatial task ...[more]