Ontology highlight
ABSTRACT:
SUBMITTER: Aksit MA
PROVIDER: S-EPMC7236628 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Aksit Melis A MA Pace Rhonda G RG Vecchio-Pagán Briana B Ling Hua H Rommens Johanna M JM Boelle Pierre-Yves PY Guillot Loic L Raraigh Karen S KS Pugh Elizabeth E Zhang Peng P Strug Lisa J LJ Drumm Mitch L ML Knowles Michael R MR Cutting Garry R GR Corvol Harriet H Blackman Scott M SM
The Journal of clinical endocrinology and metabolism 20200501 5
<h4>Context</h4>Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, the gene responsible for CF, and other genetic variants.<h4>Objective</h4>To identify genetic modifiers of CFRD and determine the genetic overlap with other types of diabetes.<h4>Design and patients</h4 ...[more]