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Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.

ABSTRACT: Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, need for mechanical ventilation, and higher mortality. Clinicians need to be more aggressive when treating obese, especially severely obese, patients with COVID-19 infection.

SUBMITTER: Sanchis-Gomar F

PROVIDER: S-EPMC7236707 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.

Sanchis-Gomar Fabian F Lavie Carl J CJ Mehra Mandeep R MR Henry Brandon Michael BM Lippi Giuseppe G

Mayo Clinic proceedings 20200519 7

Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is high ...[more]

PMID: 32622449

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