Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of the articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the epidermal growth factor receptor (EGFR). Cartilage-specific Mig-6 knockout (KO) mice display increased EGFR signaling, an anabolic buildup of the articular cartilage, and formation of chondro-osseous nodules. Since our understanding of the EGFR/Mig-6 network in the cartilage remains incomplete, we characterized mice with cartilage-specific overexpression of Mig-6 in this study.

Methods

Utilizing knee joints from cartilage-specific Mig-6-overexpressing (Mig-6^over/over) mice (at multiple time points), we evaluated the articular cartilage using histology, i

SUBMITTER: Bellini M 

PROVIDER: S-EPMC7236969 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature