Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study.

ABSTRACT: Cardioversion and defibrillation by a single high energy shock applied by myocardial or body surface electrodes is painful, causes long term tissue damage, and is associated with worsening long term outcomes, but is almost always required for treatment of ventricular fibrillation . As a initial step towards developing methods that can terminate ventricular arrhythmias painlessly, we aim to determine if pacing stimuli at a rate of 5/s applied via an implantable cardiac defibrillator (ICD) can modify human ventricular fibrillation. In 8 patients undergoing defibrillation testing of a new/exchanged intracardiac defibrillator, five seconds of pacing at five stimuli per second was applied during the 10-20 seconds of induced ventricular fibrillation before the defibrillation shock was automatica

SUBMITTER: Holden AV 

PROVIDER: S-EPMC7237074 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature