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A self-adhesive microneedle patch with drug loading capability through swelling effect.

ABSTRACT: Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 ?g?cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.

SUBMITTER: Chew SWT

PROVIDER: S-EPMC7237146 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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A self-adhesive microneedle patch with drug loading capability through swelling effect.

Chew Sharon W T SWT Shah Ankur H AH Zheng Mengjia M Chang Hao H Wiraja Christian C Steele Terry W J TWJ Xu Chenjie C

Bioengineering & translational medicine 20200229 2

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylate ...[more]

PMID: 32440562

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