Ontology highlight
ABSTRACT:
SUBMITTER: Jaffe PI
PROVIDER: S-EPMC7237207 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Jaffe Paul I PI Brainard Michael S MS
eLife 20200519
Acetylcholine is well-understood to enhance cortical sensory responses and perceptual sensitivity in aroused or attentive states. Yet little is known about cholinergic influences on motor cortical regions. Here we use the quantifiable nature of birdsong to investigate how acetylcholine modulates the cortical (pallial) premotor nucleus HVC and shapes vocal output. We found that dialyzing the cholinergic agonist carbachol into HVC increased the pitch, amplitude, tempo and stereotypy of song, simil ...[more]