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Serotonin signaling by maternal neurons upon stress ensures progeny survival.

ABSTRACT: Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny from damage in a fluctuating environment is a fundamental question in biology. We show that in Caenorhabditis elegans, serotonin released by maternal neurons during stress ensures the viability and stress resilience of future offspring. Serotonin acts through a signal transduction pathway conserved between C. elegans and mammalian cells to enable the transcription factor HSF1 to alter chromatin in soon-to-be fertilized germ cells by recruiting the histone chaperone FACT, displacing histones, and initiating protective gene expression. Without serotonin release by maternal neurons, FACT is not recruited by HSF1 in germ cells, transcription occurs but is delayed, and progeny of stressed C. elegans mothers fail to complete development. These studies uncover a novel mechanism by which stress sensing by neurons is coupled to transcription response times of germ cells to protect future offspring.

SUBMITTER: Das S

PROVIDER: S-EPMC7237211 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Serotonin signaling by maternal neurons upon stress ensures progeny survival.

Das Srijit S Ooi Felicia K FK Cruz Corchado Johnny J Fuller Leah C LC Weiner Joshua A JA Prahlad Veena V

eLife 20200423

Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny from damage in a fluctuating environment is a fundamental question in biology. We show that in <i>Caenorhabditis elegans</i>, serotonin released by maternal neurons during stress ensures the viability and stress resilience of future offspring. Serotonin acts through a signal transduction pathway conserved between <i>C. elegans</i> and mammalian cells to enable the transcription factor HSF1 to alter chromat ...[more]

PMID: 32324136

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Correction: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.

Project description:[This corrects the article DOI: 10.1371/journal.pgen.1006396.].

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