Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity.

ABSTRACT: Erythropoiesis in the bone marrow and spleen depends on intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of nuclear factor erythroid 2-related factor 2 (Nrf2) during recovery from stress erythropoiesis. To that end, we induced stress erythropoiesis in Nrf2^+/+ and Nrf2-null mice and evaluated macrophage subsets known to support erythropoiesis and erythroid cell populations. Our results confirm macrophage and erythroid hypercellularity after acute blood loss. Importantly, Nrf2 depletion results in a marked numerical reduction of F4/80⁺/CD169⁺/CD11b⁺ macrophages, which is more prominent under the induction of stress erythropoiesis. The observed macrophage deficiency is concomitant t

SUBMITTER: Gbotosho OT 

PROVIDER: S-EPMC7237317 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature