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Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis.


ABSTRACT: BACKGROUND:Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicrobial therapy might however, also negatively impact the prognosis. The usefulness of sepsis markers in diabetic ketoacidosis has not been assessed. Thus, we sought to investigate diagnostic performances of clinical and biological sepsis markers during diabetic ketoacidosis. METHODS:In this monocentric retrospective cohort study, all consecutive episodes of diabetic ketoacidosis (defined as pH ? 7.25, glycaemia > 300 mg/dL and presence of ketones) admitted in intensive care unit were included. A proven bacterial infection was defined as bacteriological documentation on any bacterial sample. Clinical (presence of fever: temperature > 38 °C and presence of hypothermia: temperature < 36 °C) and biological markers (whole blood count, neutrophils count, neutrophils-to-lymphocytes count ratio and procalcitonin), recorded at admission, were compared according to the presence or absence of a proven bacterial infection. RESULTS:Between 2011 and 2018, among 134 episodes of diabetic ketoacidosis, 102 were included (91 patients). Twenty out of 102 were infected. At admission, procalcitonin (median: 3.58 ng/mL vs 0.52 ng/mL, p?

SUBMITTER: Blanchard F 

PROVIDER: S-EPMC7237630 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis.

Blanchard Florian F   Charbit Judith J   Van der Meersch Guillaume G   Popoff Benjamin B   Picod Adrien A   Cohen Regis R   Chemouni Frank F   Gaudry Stephane S   Bihan Helene H   Cohen Yves Y  

Annals of intensive care 20200519 1


<h4>Background</h4>Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicrobial therapy might however, also negatively impact the prognosis. The usefulness of sepsis markers in diabetic ketoacidosis has not been assessed. Thus, we sought to investigate diagnostic performances of clinical and biological sepsis markers during diabetic ketoacidosis  ...[more]

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