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Suzuki-Miyaura cross coupling is not an informative reaction to demonstrate the performance of new solvents.

ABSTRACT: The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki-Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and ?-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki-Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.

SUBMITTER: Sherwood J

PROVIDER: S-EPMC7237806 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Suzuki-Miyaura cross coupling is not an informative reaction to demonstrate the performance of new solvents.

Sherwood James J

Beilstein journal of organic chemistry 20200513

The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki-Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of sol ...[more]

PMID: 32509031

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