Ontology highlight
ABSTRACT:
SUBMITTER: Yoo SM
PROVIDER: S-EPMC7237997 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pathogens (Basel, Switzerland) 20200403 4
Kaposi's sarcoma-associated herpesvirus (KSHV) modulates the immune response to allow the virus to establish persistent infection in the host and facilitate the development of KSHV-associated cancer. The complement system has a central role in the defense against pathogens. Hence, KSHV has adopted an evasion strategy for complement attack using the viral protein encoded by KSHV open reading frame 4. However, despite this defense mechanism, the complement system appears to become activated in KSH ...[more]