Ontology highlight
ABSTRACT:
SUBMITTER: Allard Q
PROVIDER: S-EPMC7238177 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Allard Quentin Q Djerada Zoubir Z Pouplard Claire C Repessé Yohann Y Desprez Dominique D Galinat Hubert H Frotscher Birgit B Berger Claire C Harroche Annie A Ryman Anne A Flaujac Claire C Chamouni Pierre P Guillet Benoît B Volot Fabienne F Szymezak Jean J Nguyen Philippe P Cazaubon Yoann Y
Pharmaceutics 20200421 4
We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model for eight factors VIII (FVIII) that could estimate individual PK parameters for targeting the desired level of FVIII activity (FVIII:C); and (2) to compare half-life (HL) in patients switching from a standard half-life (SHL) to an extended half-life (EHL) and evaluate the relevance of ...[more]