Ontology highlight
ABSTRACT:
SUBMITTER: Driscoll MK
PROVIDER: S-EPMC7238333 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Driscoll Meghan K MK Welf Erik S ES Jamieson Andrew R AR Dean Kevin M KM Isogai Tadamoto T Fiolka Reto R Danuser Gaudenz G
Nature methods 20190909 10
Rapid developments in live-cell three-dimensional (3D) microscopy enable imaging of cell morphology and signaling with unprecedented detail. However, tools to systematically measure and visualize the intricate relationships between intracellular signaling, cytoskeletal organization and downstream cell morphological outputs do not exist. Here, we introduce u-shape3D, a computer graphics and machine-learning pipeline to probe molecular mechanisms underlying 3D cell morphogenesis and to test the in ...[more]