Long-term impairment of neurovascular coupling following experimental subarachnoid hemorrhage.

ABSTRACT: CO₂-reactivity and neurovascular coupling are sequentially lost within the first 24 h after subarachnoid hemorrhage (SAH). Whether and when these impairments recover is not known. Therefore, we investigated the reactivity of pial and intraparenchymal vessels by in vivo two-photon microscopy one month after experimental SAH. C57BL/6 mice were subjected to either sham surgery or SAH by filament perforation. One month later, cerebral blood flow following CO₂-challenge and forepaw stimulation was assessed by laser Doppler fluxmetry. Diameters of pial and intraparenchymal arterioles were quantified by in vivo two-photon microscopy. One month after SAH, pial and parenchymal vessels dilated in response to CO₂. Neurovascular coupling was almost completely absent af

SUBMITTER: Balbi M 

PROVIDER: S-EPMC7238370 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature