Ontology highlight
ABSTRACT:
SUBMITTER: Fu YY
PROVIDER: S-EPMC7239328 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Fu Ya-Yuan YY Egorova Anastasiya A Sobieski Catherine C Kuttiyara Jason J Calafiore Marco M Takashima Shuichiro S Clevers Hans H Hanash Alan M AM
Immunity 20190702 1
The key sites within the gastrointestinal (GI) tract where T cells mediate effector responses and the impact of these responses on intestinal stem cells (ISCs) remain unclear. Using experimental bone marrow transplantation to model immune-mediated GI damage and 3D imaging to analyze T cell localization, we found that the ISC compartment is the primary intestinal site targeted by T cells after transplantation. Recruitment to the crypt base region resulted in direct T cell engagement with the stem ...[more]