Ontology highlight
ABSTRACT:
SUBMITTER: Elassaiss-Schaap J
PROVIDER: S-EPMC7239339 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20200515 5
Pharmacometric models using lognormal distributions have become commonplace in pharmacokinetic-pharmacodynamic investigations. The extent to which it can be interpreted by traditional description of variability through the normal distribution remains elusive. In this tutorial, the comparison is made using formal approximation methods. The quality of the resulting approximation was assessed by the similarity of prediction intervals (PIs) to true values, illustrated using 80% PIs. Approximated PIs ...[more]