Association between chronic kidney disease and incident diagnosis of dementia in England: a cohort study in Clinical Practice Research Datalink.

ABSTRACT:

Objectives

To investigate the association between chronic kidney disease (CKD) and dementia diagnosis in a real-world primary care setting in England.

Design

Matched cohort study.

Settings

English primary care in the Clinical Practice Research Datalink.

Participants

People aged ≥18 years with predialysis CKD (stages 3-5, defined as two measurements of estimated glomerular filtration rate <60 mL/min/1.73 m² for 3 months) from 2004 to 2014, and people without known CKD who were matched on age, sex, general practice and calendar time in a 1:1 ratio.

Primary and secondary outcome measures

First-ever diagnosis of dementia recorded by GPs. We also examined all-cause death as a secondary outcome to discuss potential competing risk of mortality in the

SUBMITTER: Hiramatsu R 

PROVIDER: S-EPMC7239548 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature