Ontology highlight
ABSTRACT:
SUBMITTER: Yu YQ
PROVIDER: S-EPMC7239892 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Yu Yu-Qiang YQ Zielinska Marta M Li Wei W Bernkopf Dominic B DB Heilingloh Christiane Silke CS Neurath Markus F MF Becker Christoph C
Scientific reports 20200520 1
Viral infections trigger host innate immune responses, characterized by the production of type-I interferons (IFN) including IFNβ. IFNβ induces cellular antiviral defense mechanisms and thereby contributes to pathogen clearance. Accumulating evidence suggests that mitochondria constitute a crucial platform for the induction of antiviral immunity. Here we demonstrate that the mitochondrial protein phosphoglycerate mutase family member 5 (PGAM5) is important for the antiviral cellular response. Fo ...[more]