Brain Ischemia Significantly Alters microRNA Expression in Human Peripheral Blood Natural Killer Cells.
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ABSTRACT:
SUBMITTER: Kong Y
PROVIDER: S-EPMC7240012 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Brain Ischemia Significantly Alters microRNA Expression in Human Peripheral Blood Natural Killer Cells.
Kong Ying Y Li Shiyao S Cheng Xiaojing X Ren Honglei H Zhang Bohao B Ma Hongshan H Li Minshu M Zhang Xiao-An XA
Frontiers in immunology 20200514
Brain ischemia induces systemic immunosuppression and increases a host's susceptibility to infection. MicroRNAs (miRNAs) are molecular switches in immune cells, but the alterations of miRNAs in human immune cells in response to brain ischemia and their impact on immune defense remain elusive. Natural killer (NK) cells are critical for early host defenses against pathogens. In this study, we identified reduced counts, cytokine production, and cytotoxicity in human peripheral blood NK cells obtain ...[more]
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