Ontology highlight
ABSTRACT:
SUBMITTER: Fu K
PROVIDER: S-EPMC7240201 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Fu Kristy K March Kylie K Alexaki Aikaterini A Fabozzi Giulia G Moysi Eirini E Petrovas Constantinos C
Frontiers in immunology 20200514
The continuous development of molecular biology and protein engineering technologies enables the expansion of the breadth and complexity of protein therapeutics for <i>in vivo</i> administration. However, the immunogenicity and associated <i>in vivo</i> development of antibodies against therapeutics are a major restriction factor for their usage. The B cell follicular and particularly germinal center areas in secondary lymphoid organs are the anatomical sites where the development of antibody re ...[more]