Dataset Information

Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release.

ABSTRACT: Photoresponsive polymers have attracted increasing interest for a variety of applications. Here, we report a family of photoresponsive polypeptoid-based copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl) glycine)-co-poly(N-(2-phenylethyl) glycine) (PEG-b-PNSN-co-PNPE) synthesized by the controlled ring-opening polymerization (ROP) technique. The key feature of the design is to incorporate both o-nitrobenzyl group moiety to offer the photoresponsive property and phenethyl residues to tune the structural and amphiphilic property of the system. We demonstrate that the cleavage degree of the o-nitrobenzyl group can reach to 100% upon UV-irradiation. With delicate design, a photoresponsive vesicle-to-sphere transition has been observed that facilitates the release of the encapsulants. This work provides a facile approach to prepare a type of photoresponsive polymers with tunable properties for drug delivery.

SUBMITTER: Yang X

PROVIDER: S-EPMC7240382 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release.

Yang Xu X Wang Zhiwei Z Sun Jing J

Polymers 20200403 4

Photoresponsive polymers have attracted increasing interest for a variety of applications. Here, we report a family of photoresponsive polypeptoid-based copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl) glycine)-co-poly(N-(2-phenylethyl) glycine) (PEG-b-PNSN-co-PNPE) synthesized by the controlled ring-opening polymerization (ROP) technique. The key feature of the design is to incorporate both o-nitrobenzyl group moiety to offer the p ...[more]

PMID: 32260046

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Dataset Information

Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release.

Publications

Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release.

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