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Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility.


ABSTRACT: Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.

SUBMITTER: Molina N 

PROVIDER: S-EPMC7240519 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility.

Molina Noemi N   González Ana A   Monopoli Donato D   Mentado Belinda B   Becerra José J   Santos-Ruiz Leonor L   Vida Yolanda Y   Perez-Inestrosa Ezequiel E  

Polymers 20200401 4


Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium sur  ...[more]

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