Ontology highlight
ABSTRACT:
SUBMITTER: Ding W
PROVIDER: S-EPMC7240733 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Ding Wei W Rivera Olivia C OC Kelleher Shannon L SL Soybel David I DI
iScience 20200505 6
Macrophages release a variety of extracellular vesicles (EVs). Here we describe a previously unreported class of EVs that are released from macrophages in response to Escherichia coli endotoxin, lipopolysaccharide (LPS), that we have named "macrolets" since they are extruded as large "droplets" released from macrophages. Morphologically, macrolets are anuclear, bounded by a single lipid membrane and structurally dependent on an actin cytoskeleton. Macrolets are enriched in tetraspanins and separ ...[more]