Ontology highlight
ABSTRACT:
SUBMITTER: Zumbro E
PROVIDER: S-EPMC7240832 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
ACS omega 20200506 19
Using inspiration from biology, we can leverage multivalent binding interactions to enhance weak, monovalent binding between molecules. While most previous studies have focused on multivalent binders with uniform binding sites, new synthetic polymers might find it desirable to have multiple binding moieties along the chain. Here, we probe how patterning of heterogeneous binding sites along a polymer chain controls the binding affinity of a polymer using a reactive Brownian dynamics scheme. Unlik ...[more]