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An Integrative Approach to Assessing Diet-Cancer Relationships.


ABSTRACT: The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates 'omics' data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet-cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet-cancer relationships with multi-omic approaches are also discussed.

SUBMITTER: Murphy R 

PROVIDER: S-EPMC7241082 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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An Integrative Approach to Assessing Diet-Cancer Relationships.

Murphy Rachel R  

Metabolites 20200325 4


The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates 'omics' data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discove  ...[more]

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