Ontology highlight
ABSTRACT:
SUBMITTER: Nielsen RB
PROVIDER: S-EPMC7241262 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Alzheimer's & dementia (Amsterdam, Netherlands) 20200521 1
<h4>Introduction</h4>Cardiovascular disease increases the risk of developing Alzheimer's disease (AD), and growing evidence suggests an involvement of cerebrovascular pathology in AD. Capillary dysfunction, a condition in which capillary flow disturbances rather than arterial blood supply limit brain oxygen extraction, could represent an overlooked vascular contributor to neurodegeneration. We examined whether cortical capillary transit-time heterogeneity (CTH), an index of capillary dysfunction ...[more]