Ontology highlight
ABSTRACT:
SUBMITTER: Latham AP
PROVIDER: S-EPMC7241281 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Latham Andrew P AP Zhang Bin B
Journal of chemical theory and computation 20191213 1
Intrinsically disordered proteins (IDPs) constitute a significant fraction of eukaryotic proteomes. High-resolution characterization of IDP conformational ensembles can help elucidate their roles in a wide range of biological processes but remains challenging both experimentally and computationally. Here, we present a generic algorithm to improve the accuracy of coarse-grained IDP models using a diverse set of experimental measurements. It combines maximum entropy optimization and least-squares ...[more]