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Sequential replay of nonspatial task states in the human hippocampus.

ABSTRACT: Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with consecutive patterns corresponding to nearby states. Hippocampal sequentiality correlated with the fidelity of task representations recorded in the orbitofrontal cortex during decision-making, which were themselves related to better task performance. Our findings suggest that hippocampal replay may be important for building representations of complex, abstract tasks elsewhere in the brain and establish feasibility of investigating fast replay signals with fMRI.

SUBMITTER: Schuck NW

PROVIDER: S-EPMC7241311 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Sequential replay of nonspatial task states in the human hippocampus.

Schuck Nicolas W NW Niv Yael Y

Science (New York, N.Y.) 20190601 6447

Sequential neural activity patterns related to spatial experiences are "replayed" in the hippocampus of rodents during rest. We investigated whether replay of nonspatial sequences can be detected noninvasively in the human hippocampus. Participants underwent functional magnetic resonance imaging (fMRI) while resting after performing a decision-making task with sequential structure. Hippocampal fMRI patterns recorded at rest reflected sequentiality of previously experienced task states, with cons ...[more]

PMID: 31249030

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