Ontology highlight
ABSTRACT:
SUBMITTER: Morton AR
PROVIDER: S-EPMC7241652 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Morton Andrew R AR Dogan-Artun Nergiz N Faber Zachary J ZJ MacLeod Graham G Bartels Cynthia F CF Piazza Megan S MS Allan Kevin C KC Mack Stephen C SC Wang Xiuxing X Gimple Ryan C RC Wu Qiulian Q Rubin Brian P BP Shetty Shashirekha S Angers Stephane S Dirks Peter B PB Sallari Richard C RC Lupien Mathieu M Rich Jeremy N JN Scacheri Peter C PC
Cell 20191121 6
Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types. In glioblastoma, EGFR is preferentially co-amplified with its two endogenous enhancer elements active in the cell type of origin. These regulatory elements, their contacts, and their contribution to cell fitness are preserved on high-level circular ...[more]