Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.
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ABSTRACT:
SUBMITTER: Komaki Y
PROVIDER: S-EPMC7241787 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.
Komaki Yuji Y Debacker Clement C Djemai Boucif B Ciobanu Luisa L Tsurugizawa Tomokazu T Le Bihan Denis D
PloS one 20200521 5
The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI response became significantly higher. In contrast no significant changes in the DfMRI responses and the electrophysiological responses were observed. Those results further confirm the implications of astrocy ...[more]
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