Ontology highlight
ABSTRACT:
SUBMITTER: Ferdous A
PROVIDER: S-EPMC7242347 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Ferdous Anwarul A Wang Zhao V ZV Luo Yuxuan Y Li Dan L DL Luo Xiang X Schiattarella Gabriele G GG Altamirano Francisco F May Herman I HI Battiprolu Pavan K PK Nguyen Annie A Rothermel Beverly A BA Lavandero Sergio S Gillette Thomas G TG Hill Joseph A JA
Nature communications 20200521 1
Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and remodeling of cardiomyocytes remains unknown. Here, we report that FoxO1, but not FoxO3, activity is essential for reciprocal regulation of types II and III iodothyronine deiodinases (Dio2 and Dio3, respectively), key enzymes involved in intracellular TH metabolism. We further s ...[more]