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Heterochromatin protein 1 (HP1): interactions with itself and chromatin components.

ABSTRACT: Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual structural elements of HP1 and thereby different behavior and interaction patterns. Hence, an understanding of various interactions of the structural elements of HP1 will be of utmost importance to better elucidate chromatin dynamics in its presence. In this review, we have gathered available information about interactions of HP1 both within and with itself as well as with chromatin elements. Also, the possible implications of these interactions are discussed.

SUBMITTER: Kumar A

PROVIDER: S-EPMC7242596 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Heterochromatin protein 1 (HP1): interactions with itself and chromatin components.

Kumar Amarjeet A Kono Hidetoshi H

Biophysical reviews 20200306 2

Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual structural elements of HP1 and thereby different behavior and interaction patterns. Hence, an understanding of various interactions of the structu ...[more]

PMID: 32144738

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