Ontology highlight
ABSTRACT:
SUBMITTER: Minchell NE
PROVIDER: S-EPMC7242899 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Minchell Nicola Elizabeth NE Keszthelyi Andrea A Baxter Jonathan J
Molecular cell 20200406 4
DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress during replication. The activity of the SMC complexes cohesin and condensin are linked to both the generation and repair of DNA topological-stress-linked damage in these regions. At cohesin-enriched centromeres, cohesin activity causes the accumulatio ...[more]