Dataset Information

Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study.

ABSTRACT: Background:Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods:The data on anal canal adenocarcinoma from SEER Program, between 1973-2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival. Results:The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter. The mean age for diagnosis of AA was 68.12?±?14.02 years. Males outnumbered females by 54.8 to 45.2%. Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%). Age generally correlated with poor overall cancer survival. However, young patients (age <40 years) also showed poor long-term survival. Patients with localized disease and well-differentiated tumors showed better survival outcomes. Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p < 0.01). Conclusions:Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups. Surgery significantly improves odds of survival and should be offered to patients amenable to intervention.

SUBMITTER: Gogna S

PROVIDER: S-EPMC7243005 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study.

Gogna Shekhar S Bergamaschi Roberto R Kajmolli Agon A Gachabayov Mahir M Rojas Aram A Samson David D Latifi Rifat R Dong Xiang Da XD

International journal of surgical oncology 20200513

<h4>Background</h4>Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States.<h4>Methods</h4>The data on anal canal adenocarcinoma from SEER Program, between 1973-2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival.<h4>Results</h4>The incidence of AA increa ...[more]

PMID: 32455011

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Dataset Information

Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study.

Publications

Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study.

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