Maximal Perfect Haplotype Blocks with Wildcards.
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ABSTRACT:
SUBMITTER: Williams L
PROVIDER: S-EPMC7243190 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Maximal Perfect Haplotype Blocks with Wildcards.
Williams Lucia L Mumey Brendan B
iScience 20200511 6
Recent work provides the first method to measure the relative fitness of genomic variants within a population that scales to large numbers of genomes. A key component of the computation involves finding maximal perfect haplotype blocks from a set of genomic samples for which SNPs (single-nucleotide polymorphisms) have been called. Often, owing to low read coverage and imperfect assemblies, some of the SNP calls can be missing from some of the samples. In this work, we consider the problem of fin ...[more]
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