Ontology highlight
ABSTRACT:
SUBMITTER: O'Driscoll C
PROVIDER: S-EPMC7243855 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
O'Driscoll Cliona C Kaufmann Walter E WE Bressler Joseph J
Brain research 20121102
The pluripotent P19 embryo carcinoma cell line was studied to determine a signaling pathway regulating MeCP2 expression. P19 cells were induced to differentiate into neurons by RA and express β-III tubulin at one day after induction and synaptophysin by 7 days. MeCP2 was first observed after β-III tubulin expression was detected and continued to rise over the course of differentiation. Both Mecp2 e1 and e2 mRNA forms progressively increased in differentiating cells. MeCP2 expression was increase ...[more]