TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.
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ABSTRACT:
SUBMITTER: Krauth N
PROVIDER: S-EPMC7243865 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.
Krauth Nathalie N Khalil Valentina V Jariwala Meet M Mermet-Joret Noemie N Vestergaard Anne-Katrine AK Capogna Marco M Nabavi Sadegh S
Frontiers in cellular neuroscience 20200512
A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs. ...[more]
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