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TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.

ABSTRACT: A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.

SUBMITTER: Krauth N 

PROVIDER: S-EPMC7243865 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.

Krauth Nathalie N   Khalil Valentina V   Jariwala Meet M   Mermet-Joret Noemie N   Vestergaard Anne-Katrine AK   Capogna Marco M   Nabavi Sadegh S  

Frontiers in cellular neuroscience 20200512

A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs. ...[more]

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