Ontology highlight
ABSTRACT:
SUBMITTER: Jiao C
PROVIDER: S-EPMC7244043 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Jiao Chenchen C Meng Tong T Zhou Chenyu C Wang Xinbo X Wang Ping P Lu Meiling M Tan Xiao X Wei Qing Q Ge Xin X Jin Jiali J
Aging 20200501 9
SPOP, a substrate binding adaptor of E3 ubiquitin ligase Cullin3, is frequently mutated in human prostate cancer (PCa). However, whether and how SPOP is regulated at transcriptional level in PCa remain unclear. Here, we report that <i>SPOP</i> is down-regulated in PCa stem-like cells (CSCs) and tissues. Our study reveals that SPOP expression is repressed by TGF-β / SMAD signaling axis in PCa CSCs. <i>SPOP</i> promoter contains SMAD-binding elements (SBEs), which can interact with SMAD3. Moreover ...[more]