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A novel method for calculating mean erythrocyte age using erythrocyte creatine.

ABSTRACT: Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age (M_RBC) from EC.We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of ⁵¹Cr.M_RBC and log_e EC showed excellent significant linearity (r = -0.9475, p < 0.001), proving that it could be treated as a mono-exponential relationship within the studied range (EC: 1.45 - 11.76 ?mol/g Hb). We established an equation to obtain M_RBC (days) from EC (?mol/g Hb): M_RBC = -22.84log_e EC + 65.83.This equation allowed calculation of M_RBC based on EC which has practical applications such as the diagnosis of anemia.

SUBMITTER: Kameyama M

PROVIDER: S-EPMC7244067 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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A novel method for calculating mean erythrocyte age using erythrocyte creatine.

Kameyama Masashi M Koga Masafumi M Okumiya Toshika T

Aging 20200511 9

Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age (MRBC) from EC.We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of 51Cr.<i ...[more]

PMID: 32392179

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Dataset Information

A novel method for calculating mean erythrocyte age using erythrocyte creatine.

Publications

A novel method for calculating mean erythrocyte age using erythrocyte creatine.

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