Ontology highlight
ABSTRACT:
SUBMITTER: Pan Q
PROVIDER: S-EPMC7244070 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pan Qingjun Q Lu Xing X Zhao Chunfei C Liao Shuzhen S Chen Xiaoqun X Guo Fengbiao F Yang Chen C Liu Hua-Feng HF
Aging 20200501 9
Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2 diabetes mellitus with obesity. Emerging evidence suggests that metformin also exerts protective effects against various kidney diseases. Some postulate that kidney disease is actually a metabolic disease, accompanied by nonresolving pathophysiologic pathways controlling oxidative stress, endoplasmic reticulum stress, inflammation, lipotoxicity, fibrosis, and senescence, as well as insufficient host defense ...[more]