Ontology highlight
ABSTRACT:
SUBMITTER: Hudobenko J
PROVIDER: S-EPMC7244081 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hudobenko Jacob J Ganesh Bhanu Priya BP Jiang Jianjun J Mohan Eric C EC Lee Songmi S Sheth Sunil S Morales Diego D Zhu Liang L Kofler Julia K JK Pautler Robia G RG McCullough Louise D LD Chauhan Anjali A
Aging 20200504 9
Growth differentiation factor (GDF) 11 levels decline with aging. The age-related loss of GDF 11 has been implicated in the pathogenesis of a variety of age-related diseases. GDF11 supplementation reversed cardiac hypertrophy, bone loss, and pulmonary dysfunction in old mice, suggesting that GDF11 has a rejuvenating effect. Less is known about the potential of GDF11 to improve recovery after an acute injury, such as stroke, in aged mice. GDF11/8 levels were assessed in young and aged male mice a ...[more]