Ontology highlight
ABSTRACT:
SUBMITTER: Besedovsky L
PROVIDER: S-EPMC7245114 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Besedovsky Luciana L Benischke Mona M Fischer Jörg J Yazdi Amir S AS Born Jan J
Proceedings of the National Academy of Sciences of the United States of America 20200504 20
Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is sufficient to trigger an allergic response-but only if participants had slept after allergen exposure. This context-conditioning effect was entirely absent when participants stayed ...[more]