Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial.
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SUBMITTER: Singh JSS
PROVIDER: S-EPMC7245350 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial.
Singh Jagdeep S S JSS Mordi Ify R IR Vickneson Keeran K Fathi Amir A Donnan Peter T PT Mohan Mohapradeep M Choy Anna Maria J AMJ Gandy Stephen S George Jacob J Khan Faisel F Pearson Ewan R ER Houston J Graeme JG Struthers Allan D AD Lang Chim C CC
Diabetes care 20200403 6
<h4>Objective</h4>To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.<h4>Research design and methods</h4>We randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10 mg daily or placebo for 1 year, on top of usual therapy. The primary end point was difference in LV end-systolic volume (LVESV) using cardiac MRI. Key secondary end points included other ...[more]
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