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Medroxyprogesterone acetate concentrations among HIV-infected depot-medroxyprogesterone acetate users receiving antiretroviral therapy in Lilongwe, Malawi.


ABSTRACT: OBJECTIVE:To compare medroxyprogesterone acetate (MPA) concentrations between HIV-positive women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable. STUDY DESIGN:Secondary analysis of 28 HIV-positive women on non-nucleoside reverse transcriptase inhibitor-containing ART regimens and 10 HIV-negative women randomized to initiate DMPA in a clinical trial of progestin contraception in Malawi. RESULTS:MPA concentrations were significantly lower among HIV-positive women on ART, compared with HIV-negative women, at week 4 and week 13 (p=.03 for both), but not at day 3 or week 26 post-DMPA initiation. CONCLUSIONS:Antiretroviral medications may affect MPA metabolism in HIV-positive African women.

SUBMITTER: Zia Y 

PROVIDER: S-EPMC7245365 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Medroxyprogesterone acetate concentrations among HIV-infected depot-medroxyprogesterone acetate users receiving antiretroviral therapy in Lilongwe, Malawi.

Zia Yasaman Y   Tang Jennifer H JH   Chinula Lameck L   Tegha Gerald G   Stanczyk Frank Z FZ   Kourtis Athena P AP  

Contraception 20190730 5


<h4>Objective</h4>To compare medroxyprogesterone acetate (MPA) concentrations between HIV-positive women on antiretroviral therapy (ART) and HIV-negative women initiating depot medroxyprogesterone (DMPA) injectable.<h4>Study design</h4>Secondary analysis of 28 HIV-positive women on non-nucleoside reverse transcriptase inhibitor-containing ART regimens and 10 HIV-negative women randomized to initiate DMPA in a clinical trial of progestin contraception in Malawi.<h4>Results</h4>MPA concentrations  ...[more]

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