CpG-creating mutations are costly in many human viruses.
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ABSTRACT:
SUBMITTER: Caudill VR
PROVIDER: S-EPMC7245597 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
CpG-creating mutations are costly in many human viruses.
Caudill Victoria R VR Qin Sarina S Winstead Ryan R Kaur Jasmeen J Tisthammer Kaho K Pineda E Geo EG Solis Caroline C Cobey Sarah S Bedford Trevor T Carja Oana O Eggo Rosalind M RM Koelle Katia K Lythgoe Katrina K Regoes Roland R Roy Scott S Allen Nicole N Aviles Milo M Baker Brittany A BA Bauer William W Bermudez Shannel S Carlson Corey C Castellanos Edgar E Catalan Francisca L FL Chemel Angeline Katia AK Elliot Jacob J Evans Dwayne D Fiutek Natalie N Fryer Emily E Goodfellow Samuel Melvin SM Hecht Mordecai M Hopp Kellen K Hopson E Deshawn ED Jaberi Amirhossein A Kinney Christen C Lao Derek D Le Adrienne A Lo Jacky J Lopez Alejandro G AG López Andrea A Lorenzo Fernando G FG Luu Gordon T GT Mahoney Andrew R AR Melton Rebecca L RL Nascimento Gabriela Do GD Pradhananga Anjani A Rodrigues Nicole S NS Shieh Annie A Sims Jasmine J Singh Rima R Sulaeman Hasan H Thu Ricky R Tran Krystal K Tran Livia L Winters Elizabeth J EJ Wong Albert A Pennings Pleuni S PS
Evolutionary ecology 20200424 3
Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, it is thought that CpG sites are rare because they are prone to mutation when methylated. In viruses, we know less about why CpG sites are rare. A previous study in HIV suggested that CpG-creating transition mutations are more costly than similar non-Cp ...[more]
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