Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study.

ABSTRACT:

Background

In two recent randomized controlled trials, withholding parenteral nutrition early in critical illness improved outcome as compared to early up-to-calculated-target nutrition, which may be explained by beneficial effects of fasting. Outside critical care, fasting-mimicking diets were found to maintain fasting-induced benefits while avoiding prolonged starvation. It is unclear whether critically ill patients can develop a fasting response after a short-term nutrient interruption. In this randomized crossover pilot study, we investigated whether 12-h nutrient interruption initiates a metabolic fasting response in prolonged critically ill patients. As a secondary objective, we studied the feasibility of monitoring autophagy in blood samples.

Methods

In a single-cente

SUBMITTER: Van Dyck L 

PROVIDER: S-EPMC7245817 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature