Insights on early mutational events in SARS-CoV-2 virus reveal founder effects across geographical regions.
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ABSTRACT:
SUBMITTER: Farkas C
PROVIDER: S-EPMC7246029 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Insights on early mutational events in SARS-CoV-2 virus reveal founder effects across geographical regions.
Farkas Carlos C Fuentes-Villalobos Francisco F Garrido Jose Luis JL Haigh Jody J Barría María Inés MI
PeerJ 20200521
Here we aim to describe early mutational events across samples from publicly available SARS-CoV-2 sequences from the sequence read archive and GenBank repositories. Up until 27 March 2020, we downloaded 50 illumina datasets, mostly from China, USA (WA State) and Australia (VIC). A total of 30 datasets (60%) contain at least a single founder mutation and most of the variants are missense (over 63%). Five-point mutations with clonal (founder) effect were found in USA next-generation sequencing sam ...[more]
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